![]() ![]() Key: 3TC = lamivudine ART = antiretroviral therapy CNS = central nervous system CYP = cytochrome P DOR = doravirine EFV = efavirenz FTC = emtricitabine H2 = histamine 2 PPI = proton pump inhibitor RPV = rilpivirine STR = single-tablet regimen TAF = tenofovir alafenamide TDF = tenofovir disoproxil fumarateĪ See Optimizing Antiretroviral Therapy in the Setting of Virologic Suppression and Appendix B Table 4 for information regarding injectable RPV.įive NNRTIs-delavirdine (DLV), doravirine (DOR), efavirenz (EFV), etravirine (ETR), nevirapine (NVP), and rilpivirine (RPV)-currently are approved by the Food and Drug Administration (FDA) for the treatment of HIV when used in combination with other antiretroviral (ARV) drugs. Use of RPV with PPIs is not recommended see Drug–Drug Interactions for dosing recommendations when RPV is coadministered with H2 blocker or antacids. RPV oral absorption is reduced with increased gastric pH. CNS side effects, including dizziness, abnormal dreams, headache, depression, suicidality, insomnia, somnolenceĬYP3A4 substrate, mixed inducer/inhibitor. ![]() Characteristics of Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) that are Recommended as Initial Therapy for People with HIV Characteristics
0 Comments
Leave a Reply. |